Biostatistics gives us the : [ PRS = \sum (EffectSize_i \times NumberOfRiskAlleles_i) ]

If you test 20,000 genes for association with a disease, you will find 1,000 "significant" results just by random chance (at ( p < 0.05 )).

If you have ever looked at a printout of a DNA sequence—those endless rows of A, T, C, and G—you know it looks like chaos. Hidden within that chaos are the variants: the single nucleotide polymorphisms (SNPs), the insertions, the deletions. These tiny changes are what make you unique, but they are also what can cause disease.